Authors
Muhammad Izzad Johari, Khairiah Yusoff, Juhara Haron, Chandran Nadarajan, Khairun Nisah Ibrahim, Mung Seong Wong, Muhammad Ilham Abdul Hafidz, Bee Eng Chua, Nurhazwani Hamid, Wan Nor Arifin, Zheng Feei Ma, Yeong Yeh Lee
Publication date
2019/8/2
Journal
Scientific reports
Volume
9
Issue
1
Pages
11232
Publisher
Nature Publishing Group UK
Description
Currently, there is no effective therapy for non-alcoholic fatty liver disease (NAFLD), and although calorie restriction is recommended in guidelines, but adherence is an issue. The current study aimed to determine the effectiveness of eight weeks intermittent fasting (IF) strategy in the control of NAFLD activity and the adherence rate of such strategy. This was a randomized controlled trial with modified alternate-day calorie restriction (MACR), a form of IF, as the active intervention and usual habitual diet as control. The outcome measures included changes in body mass index (BMI), blood lipids (cholesterol, LDL, HDL and triglyceride), fasting blood sugar (FBS), liver enzymes (ALT and AST), and ultrasound measurements of liver steatosis and 2-dimensional shear wave elastography (SWE). Per-protocol (PP) analysis was performed with comparison within (post vs. pre-intervention) and between (MACR vs. control …
Scholar articles
MI Johari, K Yusoff, J Haron, C Nadarajan, KN Ibrahim… - Scientific reports, 2019