View article

Exercise has been suggested to ameliorate the detrimental effects of chemotherapy on skeletal muscle. The aim of this study was to compare the effects of different exercise regimens with usual care on skeletal muscle morphology and mitochondrial markers in patients being treated with chemotherapy for breast cancer. Specifically, we compared moderate‐intensity aerobic training combined with high‐intensity interval training (AT‐HIIT) and resistance training combined with high‐intensity interval training (RT‐HIIT) with usual care (UC). Resting skeletal muscle biopsies were obtained pre‐ and postintervention from 23 randomly selected women from the OptiTrain breast cancer trial who underwent RT‐HIIT, AT‐HIIT, or UC for 16 wk. Over the intervention, citrate synthase activity, muscle fiber cross‐sectional area, capillaries per fiber, and myosin heavy chain isoform type I were reduced in UC, whereas RT‐HIIT and …