Authors
Yvonne Wengström, Anita Margulies
Publication date
2008/9/1
Journal
European Journal of Oncology Nursing
Volume
12
Issue
4
Pages
357-361
Publisher
Churchill Livingstone
Description
An infrequent, but potential complication of chemotherapy is vesicant chemotherapy extravasation. Vesicants have the potential to cause blistering and ulceration when they extravasate from the vein or are inadvertently administered into the tissue. In 2007, the European Oncology Nursing Society published guidelines for extravasation prevention, detection, and management. Recommended management includes topical heating for plant alkaloid extravasations and topical cooling for anthracycline and other antitumor antibiotic vesicants. For treatment of antracycline extravasations topical dimethylsulfoxide (DMSO), sodium thiosulfate, and hyaluronidase have been described in the literature but due to lack of evidence to support their use as vesicant extravasation antidotes, it is recommended that these agents are studied further. Furthermore, Savene® (dexrazoxane) is the only registered drug for the treatment of …
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Scholar articles
Y Wengström, A Margulies - European Journal of Oncology Nursing, 2008