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Delay and packet loss dramatically affect the quality of voice-over-IP (VoIP) calls and depend on the playout buffer scheme implemented at the receiver. The choice of playout algorithm can't be based on statistical metrics without considering the perceived end-to-end conversational speech quality. The authors present a method for evaluating various playout algorithms that extends the E-model concept by estimating user satisfaction from time-varying transmission impairments. This article evaluates several playout algorithms and shows a correspondence between the authors' results and those obtained via statistical loss and delay metrics.