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The challenging task of a CMOS image sensor is to have a well robust compression processor for multimedia and medical applications because it requires huge storage requirement of image data like small bowel images, retinal images and mammograms from different modalities such as ultra sonography, magnetic resonance imaging, computed tomography and media files. To overcome image degradation at high compression ratio (CR), we have proposed an integrated compression technique which combines quadrant tree decomposition (QTD) and lifting based discrete wavelet transform (DWT) to provide promising results with high compression at low bit rates without losing any information of the image and the advancement in technology such as backside illumination makes CMOS sensor to use in medical imaging application. The input image is undergone QTD coding followed by lifting based DWT …