Authors
Andrew G Clark, Michael B Eisen, Douglas R Smith, Casey M Bergman, Brian Oliver, Therese A Markow, Thomas C Kaufman, Manolis Kellis, William Gelbart, Venky N Iyer, Daniel A Pollard, Timothy B Sackton, Amanda M Larracuente, Nadia D Singh, Jose P Abad, Dawn N Abt, Boris Adryan, Montserrat Aguade, Hiroshi Akashi, Wyatt W Anderson, Charles F Aquadro, David H Ardell, Roman Arguello, Carlo G Artieri, Daniel A Barbash, Daniel Barker, Paolo Barsanti, Phil Batterham, Serafim Batzoglou, Dave Begun, Arjun Bhutkar, Enrico Blanco, Stephanie A Bosak, Robert K Bradley, Adrianne D Brand, Michael R Brent, Angela N Brooks, Randall H Brown, Roger K Butlin, Corrado Caggese, Brian R Calvi, A Bernardo De Carvalho, Anat Caspi, Sergio Castrezana, Susan E Celniker, Jean L Chang, Charles Chapple, Sourav Chatterji, Asif Chinwalla, Alberto Civetta, Sandra W Clifton, Josep M Comeron, James C Costello, Jerry A Coyne, Jennifer Daub, Robert G David, Arthur L Delcher, Kim Delehaunty, Chuong B Do, Heather Ebling, Kevin Edwards, Thomas Eickbush, Jay D Evans, Alan Filipski, Sven Findeiß, Eva Freyhult, Lucinda Fulton, Robert Fulton, Ana CL Garcia, Anastasia Gardiner, David A Garfield, Barry E Garvin, Greg Gibson, Don Gilbert, Sante Gnerre, Jennifer Godfrey, Robert Good, Valer Gotea, Brenton Gravely, Anthony J Greenberg, Sam Griffiths-Jones, Samuel Gross, Roderic Guigo, Erik A Gustafson, Wilfried Haerty, Matthew W Hahn, Daniel L Halligan, Aaron L Halpern, Gillian M Halter, Mira V Han, Andreas Heger, LaDeana Hillier, Angie S Hinrichs, Ian Holmes, Roger A Hoskins, Melissa J Hubisz, Dan Hultmark, Melanie A Huntley, David B Jaffe, Santosh Jagadeeshan, William R Jeck, Justin Johnson, Corbin D Jones, William C Jordan, Gary H Karpen, Eiko Kataoka, Peter D Keightley, Pouya Kheradpour, Ewen F Kirkness, Leonardo B Koerich, Karsten Kristiansen, Dave Kudrna, Rob J Kulathinal, Sudhir Kumar, Roberta Kwok, Eric Lander, Charles H Langley, Richard Lapoint, Brian P Lazzaro, So-Jeong Lee, Lisa Levesque, Ruiqiang Li, Chiao-Feng Lin, Michael F Lin, Kerstin Lindblad-Toh, Ana Llopart, Manyuan Long, Lloyd Low, Elena Lozovsky, Jian Lu, Meizhong Luo, Carlos A Machado, Wojciech Makalowski, Mar Marzo, Muneo Matsuda, Luciano Matzkin, Bryant McAllister, Carolyn S McBride, Brendan McKernan, Kevin McKernan, Maria Mendez-Lago, Patrick Minx, Michael U Mollenhauer, Kristi Montooth, Stephen M Mount, Xu Mu, Eugene Myers, Barbara Negre, Stuart Newfeld, Rasmus Nielsen
Publication date
2007
Journal
Nature
Volume
450
Issue
7167
Pages
203-18
Description
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
Total citations
Scholar articles
AG Clark, MB Eisen, DR Smith, CM Bergman, B Oliver… - Nature, 2007
A Clark, M Eisen, D Smith, C Bergman, W Gelbart… - Nature, 2007