Authors
Michael R Emmert-Buck, Larisa V Debelenko, Sunita Agarwal, Mary Beth Kester, Pachiappan Manickam, Zhengping Zhuang, Siradanahalli C Guru, Shodimu-Emmanuel Olufemi, A Lee Burns, Settara C Chandrasekharappa, Irina A Lubensky, Lance A Liotta, Monica C Skarulis, Allen M Spiegel, Stephen J Marx, Francis S Collins
Publication date
1998/2/1
Journal
Molecular genetics and metabolism
Volume
63
Issue
2
Pages
151-155
Publisher
Academic Press
Description
We analyzed constitutional and tumor DNA from 27 MEN1 kindreds not known to be related to each other. Disease allele haplotypes were constructed for each pedigree based on shared alleles from two or more affected members and from determination of allelic loss patterns in their tumors. Analysis of disease allele haplotypes showed unexpected linkage disequilibrium at markerPYGM.Further haplotype analysis indicated this could be explained by the presence of two founder chromosomes, one in four families, the other in three. A shared disease haplotype was not observed among two MEN1 kindreds with the prolactinoma phenotype of MEN1.
Scholar articles
MR Emmert-Buck, LV Debelenko, S Agarwal… - Molecular genetics and metabolism, 1998