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This study examined acculturative stress and self-esteem as mediators of the association of ethnic identity and acculturation with psychosocial outcomes. The study sample consisted of 347 Hispanic adolescents in a" new" immigrant-receiving community in the Midwest. The authors expected acculturation to influence psychosocial adjustment through acculturative stress and ethnic identity to influence psychosocial adjustment through self-esteem. Results indicated that relationships of ethnic identity to academic grades and to externalizing symptoms were mediated by self-esteem and that both US and Hispanic acculturation orientations were directly associated with prosocial behavior. The relationships of US cultural orientation to academic grades and to behavior problems were mediated through acculturative stress and self-esteem. Implications of these findings for the study of Hispanics in more monocultural …