Authors
Dean B Andropoulos, Hasan B Ahmad, Taha Haq, Ken Brady, Stephen A Stayer, Marcie R Meador, Jill V Hunter, Carlos Rivera, Robert G Voigt, Marie Turcich, Cathy Q He, Lara S Shekerdemian, Heather A Dickerson, Charles D Fraser, E Dean McKenzie, Jeffrey S Heinle, R Blaine Easley
Publication date
2014/3
Journal
Pediatric Anesthesia
Volume
24
Issue
3
Pages
266-274
Description
Background
Adverse neurodevelopmental outcomes are observed in up to 50% of infants after complex cardiac surgery. We sought to determine the association of perioperative anesthetic exposure with neurodevelopmental outcomes at age 12 months in neonates undergoing complex cardiac surgery and to determine the effect of brain injury determined by magnetic resonance imaging (MRI).
Methods
Retrospective cohort study of neonates undergoing complex cardiac surgery who had preoperative and 7‐day postoperative brain MRI and 12‐month neurodevelopmental testing with Bayley Scales of Infant and Toddler Development, Third Edition (Bayley‐III). Doses of volatile anesthetics (VAA), benzodiazepines, and opioids were determined during the first 12 months of life.
Results
From a database of 97 infants, 59 met inclusion criteria. Mean ± sd composite standard scores were as follows: cognitive = 102.1 …
Scholar articles
DB Andropoulos, HB Ahmad, T Haq, K Brady… - Pediatric Anesthesia, 2014