Authors
J William Gaynor, Christian Stopp, David Wypij, Dean B Andropoulos, Joseph Atallah, Andrew M Atz, John Beca, Mary T Donofrio, Kim Duncan, Nancy S Ghanayem, Caren S Goldberg, Hedwig Hövels-Gürich, Fukiko Ichida, Jeffrey P Jacobs, Robert Justo, Beatrice Latal, Jennifer S Li, William T Mahle, Patrick S McQuillen, Shaji C Menon, Victoria L Pemberton, Nancy A Pike, Christian Pizarro, Lara S Shekerdemian, Anne Synnes, Ismee Williams, David C Bellinger, Jane W Newburger, International Cardiac Collaborative on Neurodevelopment (ICCON) Investigators
Publication date
2015/5/1
Journal
Pediatrics
Volume
135
Issue
5
Pages
816-825
Publisher
American Academy of Pediatrics
Description
BACKGROUND
Neurodevelopmental disability is the most common complication for survivors of surgery for congenital heart disease (CHD).
METHODS
We analyzed individual participant data from studies of children evaluated with the Bayley Scales of Infant Development, second edition, after cardiac surgery between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), and the secondary outcome was Mental Development Index (MDI).
RESULTS
Among 1770 subjects from 22 institutions, assessed at age 14.5 ± 3.7 months, PDIs and MDIs (77.6 ± 18.8 and 88.2 ± 16.7, respectively) were lower than normative means (each P < .001). Later calendar year of birth was associated with an increased proportion of high-risk infants (complexity of CHD and prevalence of genetic/extracardiac anomalies). After adjustment for center and type …
Scholar articles
JW Gaynor, C Stopp, D Wypij, DB Andropoulos… - Pediatrics, 2015