Authors
Dean B Andropoulos, Jill V Hunter, David P Nelson, Stephen A Stayer, Ann R Stark, E Dean McKenzie, Jeffrey S Heinle, Daniel E Graves, Charles D Fraser Jr
Publication date
2010/3/1
Journal
The Journal of thoracic and cardiovascular surgery
Volume
139
Issue
3
Pages
543-556
Publisher
Mosby
Description
BACKGROUND
New intraparenchymal brain injury on magnetic resonance imaging is observed in 36% to 73% of neonates after cardiac surgery with cardiopulmonary bypass. Brain immaturity in this population is common. We performed brain magnetic resonance imaging before and after neonatal cardiac surgery, using a high-flow cardiopulmonary bypass protocol, hypothesizing that brain injury on magnetic resonance imaging would be associated with brain immaturity.
METHODS
Cardiopulmonary bypass protocol included 150 mL · kg−1 · min−1 flows, pH stat management, hematocrit > 30%, and high-flow antegrade cerebral perfusion. Regional brain oxygen saturation was monitored, with a treatment protocol for regional brain oxygen saturation < 50%. Brain magnetic resonance imaging, consisting of T1-, T2-, and diffusion-weighted imaging, and magnetic resonance spectroscopy were performed …
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Scholar articles
DB Andropoulos, JV Hunter, DP Nelson, SA Stayer… - The Journal of thoracic and cardiovascular surgery, 2010