Authors
Charles D Fraser III, Ken M Brady, Christopher J Rhee, R Blaine Easley, Kathleen Kibler, Peter Smielewski, Marek Czosnyka, David W Kaczka, Dean B Andropoulos, Craig Rusin
Publication date
2013/7/1
Journal
Journal of Applied Physiology
Volume
115
Issue
1
Pages
52-56
Publisher
American Physiological Society
Description
The frequency-response of pressure autoregulation is not well delineated; therefore, the optimal frequency of arterial blood pressure (ABP) modulation for measuring autoregulation is unknown. We hypothesized that cerebrovascular autoregulation is band-limited and delineated by a cutoff frequency for which ABP variations induce cerebrovascular reactivity. Neonatal swine (n = 8) were anesthetized using constant minute ventilation while positive end-expiratory pressure (PEEP) was modulated between 6 and 0.75 cycles/min (min−1). The animals were hemorrhaged until ABP was below the lower limit of autoregulation (LLA), and PEEP modulations were repeated. Vascular reactivity was quantified at each frequency according to the phase lag between ABP and intracranial pressure (ICP) above and below the LLA. Phase differences between ABP and ICP were small for frequencies of >2 min−1, with no ability to …
Total citations
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Scholar articles
CD Fraser III, KM Brady, CJ Rhee, RB Easley, K Kibler… - Journal of Applied Physiology, 2013