Authors
Shannon M Rivenes, Mark B Lewin, Stephen A Stayer, Sabrina T Bent, Heather M Schoenig, E Dean McKenzie, Charles D Fraser, Dean B Andropoulos
Publication date
2001/2/1
Journal
The Journal of the American Society of Anesthesiologists
Volume
94
Issue
2
Pages
223-229
Publisher
The American Society of Anesthesiologists
Description
Background
The cardiovascular effects of halogenated anesthetic agents in children with normal hearts have been studied, but data in children with cardiac disease are limited. This study compared the effects of halothane, isoflurane, sevoflurane, and fentanyl-midazolam on systemic and pulmonary hemodynamics and myocardial contractility in patients with congenital heart disease.
Methods
Fifty-four patients younger than age 14 scheduled to undergo congenital heart surgery were randomized to receive halothane, sevoflurane, isoflurane, or fentanyl-midazolam. Cardiovascular and echocardiographic data were recorded at baseline and at randomly ordered 1 and 1.5 minimum alveolar concentrations, or predicted equivalent fentanyl-midazolam plasma concentrations. The shortening fraction and ejection fraction (using the modified Simpson rule) were calculated. Cardiac index …
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Scholar articles
SM Rivenes, MB Lewin, SA Stayer, ST Bent… - The Journal of the American Society of …, 2001