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Results

In total 241 patients were included in the study. In four cases the genotype could not be obtained (two for each gene). No departure from Hardy-Weinberg equilibrium was observed. Neuropathy grade 2 or worse was registered for 65 patients (27%). See Table I for neuropathy distribution across genotypes. Neuropathy hazard ratios for RWDD3 (per allele) and TECTA (wt/wt+ wt/var vs. var/var) were 0.95 [95% CI 0.57–1.58], p-value 0.84 (see Figure 1) and 0.21 [95% CI 0.03–1.53], p-value 0.12 (see Figure 2), respectively. For TECTA using the trend model (wt/wt vs. wt/var vs. var/var) the neuropathy hazard ratio was 0.98 [95% CI 0.65–1.46], p-value 0.91. P-values for the likelihood-ratio test of equality between obtained hazard ratios and reported ones were 0.0628 and 0.0007 for RWDD3 and TECTA, respectively.