Authors
Rasmus S Pedersen, Charlotte Brasch-Andersen, Sarah C Sim, Troels K Bergmann, Jónrit Halling, Maria S Petersen, Pál Weihe, Hege Edvardsen, Vessela N Kristensen, Kim Brøsen, Magnus Ingelman-Sundberg
Publication date
2010/12
Journal
European journal of clinical pharmacology
Volume
66
Pages
1199-1205
Publisher
Springer-Verlag
Description
Purpose
To determine the distribution of clinically important CYP2C genotypes and allele frequencies in healthy Nordic populations with special focus on linkage disequilibrium.
Methods
A total of 896 healthy subjects from three Nordic populations (Danish, Faroese, and Norwegian) were genotyped for five frequent and clinically important CYP2C allelic variants: the defective CYP2C8*3, CYP2C9*2, CYP2C9*3, and CYP2C19*2 alleles, and the CYP2C19*17 allele that causes rapid drug metabolism. Linkage disequilibrium was evaluated and CYP2C haplotypes were inferred in the entire population.
Results
Ten CYP2C haplotypes were inferred, the most frequent of which (49%) was the CYP2C wildtype haplotype carrying CYP2C8*1, CYP2C9*1, and CYP2C19*1. The second most frequent haplotype (19%) is composed …
Total citations
Scholar articles
RS Pedersen, C Brasch-Andersen, SC Sim… - European journal of clinical pharmacology, 2010