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Introduction mechanisms that mediate myocardial remodeling at the cellular level has led to evidence that reactive In the setting of hemodynamic overload, there are progressive changes in myocardial structure and oxygen species (ROS) and oxidative stress play a central role in regulating the phenotype of cardiac function that are referred to as myocardial remodeling. This process is characterized by vent- myocytes and fibroblasts. In this brief review, we will discuss the experimental evidence for the role ricular enlargement, alterations in chamber geometry and pump dysfunction. 1 At the cellular of oxidative stress in the pathogenesis of myocardial remodeling leading to heart failure and delve into level, the changes in ventricular structure in heart failure include myocyte growth, 2 loss of myocytes the potential cellular mechanisms by which ROS and oxidative stress might contribute to this disease via apoptosis or …