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The introduction of modern technologies in manufacturing is contributing to the emergence of smart (and data-driven) manufacturing systems, known as Industry 4.0. The benefits of adopting such technologies can be fully utilized by presenting optimization models in every step of the decision-making process. This includes the optimization of maintenance plans and production schedules, which are two essential aspects of any manufacturing process. In this paper, we consider the real-time joint optimization of maintenance planning and production scheduling in smart manufacturing systems. We have considered a flexible job shop production layout and addressed several issues that usually take place in practice. The addressed issues are: new job arrivals, unexpected due date changes, machine degradation, random breakdowns, minimal repairs, and condition-based maintenance (CBM). We have proposed a …