Authors
Javed Yakoob, Shahab Abid, Zaigham Abbas, Wasim Jafri, Zubair Ahmad, Rashida Ahmed, Muhammad Islam
Publication date
2009/12
Journal
BMC gastroenterology
Volume
9
Pages
1-7
Publisher
BioMed Central
Description
Background
Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU).
Methods
H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out.
Results
Two hundred and twenty-four patients were included, 141 (63%) were males with a mean age of 45 ± 16, range 16-83 years. The virulence marker cagA was associated with GU in 20(63%) (p …
Total citations
Scholar articles
J Yakoob, S Abid, Z Abbas, W Jafri, Z Ahmad, R Ahmed… - BMC gastroenterology, 2009