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Drug-induced pancreatitis studies typically focus on single-acute pancreatitis (AP) cases. Little is known about the characteristics of patients with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). The aim of the current study was to analyze the characteristics, co-risk factors, and reliability of a common causality scoring system, the Naranjo, using INSPPIRE-2 (the INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2), which is the largest multi-center prospective cohort study of ARP and CP in children. Data obtained from INSPPIRE-2 were reported by physicians, as, in the context of ARP, having≥ 1 episode drug-induced pancreatitis, or, in context of CP, as having medication exposure+/-drug-induced AP episode (s). Physicians could include multiple risk factors for a case. The following were statistically evaluated: medication (med)(ARP+ CP) versus non …