Authors
Bradley C Johnston, Stephanie SY Ma, Joshua Z Goldenberg, Kristian Thorlund, Per O Vandvik, Mark Loeb, Gordon H Guyatt
Publication date
2012/12/18
Source
Annals of internal medicine
Volume
157
Issue
12
Pages
878-888
Publisher
American College of Physicians
Description
Background
Antibiotic treatment may disturb the resistance of gastrointestinal flora to colonization. This may result in complications, the most serious of which is Clostridium difficile–associated diarrhea (CDAD).
Purpose
To assess the efficacy and safety of probiotics for the prevention of CDAD in adults and children receiving antibiotics.
Data Sources
Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, Allied and Complementary Medicine Database, Web of Science, and 12 gray-literature sources.
Study Selection
Randomized, controlled trials including adult or pediatric patients receiving antibiotics that compared any strain or dose of a specified probiotic with placebo or with no treatment control and reported the incidence of CDAD.
Data Extraction …
Total citations
Scholar articles
BC Johnston, SSY Ma, JZ Goldenberg, K Thorlund… - Annals of internal medicine, 2012
BC Johnston, JZ Goldenberg, GH Guyatt - Annals of Internal Medicine, 2013