Authors
Ying Xia, Amir Fazlollahi, Vincent Dore, Pierrick Bourgeat, Parnesh Raniga, Nick Martin, Olivier Salvado, Stephen Rose, Michelle K Lupton, Michael Breakspear, Jurgen Fripp, PISA (Prospective Imaging Study of Aging: Genes, Brain and Behaviour)
Publication date
2021/12
Journal
Alzheimer's & Dementia
Volume
17
Pages
e053113
Description
Background
The APOE‐ε4 allele is the strongest known genetic risk factor for Alzheimer’s disease (AD) and is associated with higher amyloid‐β (Aβ) deposition. White matter (WM) microstructural damages are known to occur early at the preclinical stage of AD. Although stable associations between APOE‐ε4 status and WM alternations have been reported in patients with AD and mild cognitive impairment, few studies have described WM differences in cognitively unimpaired (CU) subjects at risk of AD. We aim to investigate associations of APOE‐ε4 status and Aβ load with WM microstructural changes in mid‐age CU individuals.
Method
151 CU participants from the Prospective Imaging Study of Ageing (PISA) were included (aged 44‐66, 78% female, 77 APOE‐ε4 carriers (ε4+) and 74 non‐carriers (ε4‐)) and underwent Aβ PET and 3T MRI scans including multi‐shell diffusion‐weighted images. Aβ load was …
Scholar articles
Y Xia, A Fazlollahi, V Dore, P Bourgeat, P Raniga… - Alzheimer's & Dementia, 2021