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Artificial intelligence has the potential to transform many application domains fundamentally. One notable example is clinical radiology. A growing number of decision-making support systems are available for lesion detection and segmentation, two fundamental steps to accomplish diagnosis and treatment planning. This paper proposes a model based on the unified theory of acceptance and use of technology to study the determinants for the adoption of intelligent agents across the medical imaging workflow. We tested the model via confirmatory factor analysis and structural equation modeling using clinicians’ data from an international evaluation of healthcare practitioners. Results show an increased understanding of the vital role of security, risk, and trust in the usage intention of intelligent agents. These empirical findings provide valuable theoretical contributions to researchers by explaining the reasons behind …