Authors
James A Blumenthal, Michael A Babyak, P Murali Doraiswamy, Lana Watkins, Benson M Hoffman, Krista A Barbour, Steve Herman, W Edward Craighead, Alisha L Brosse, Robert Waugh, Alan Hinderliter, Andrew Sherwood
Publication date
2007/9/1
Journal
Psychosomatic medicine
Volume
69
Issue
7
Pages
587-596
Publisher
LWW
Description
Objective:
To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in depression compared to placebo controls.
Methods:
Between October 2000 and November 2005, we performed a prospective, randomized controlled trial (SMILE study) with allocation concealment and blinded outcome assessment in a tertiary care teaching hospital. A total of 202 adults (153 women; 49 men) diagnosed with major depression were assigned randomly to one of four conditions: supervised exercise in a group setting; home-based exercise; antidepressant medication (sertraline, 50–200 mg daily); or placebo pill for 16 weeks. Patients underwent the structured clinical interview for depression and completed the Hamilton Depression Rating Scale (HAM …
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JA Blumenthal, MA Babyak, PM Doraiswamy… - Psychosomatic medicine, 2007