Authors
Peter Willeit, Lena Tschiderer, Elias Allara, Kathrin Reuber, Lisa Seekircher, LU Gao, Ximing Liao, Eva Lonn, Hertzel C Gerstein, Salim Yusuf, Frank P Brouwers, Folkert W Asselbergs, Wiek Van Gilst, Sigmund A Anderssen, Diederick E Grobbee, John JP Kastelein, Frank LJ Visseren, George Ntaios, Apostolos I Hatzitolios, Christos Savopoulos, Pythia T Nieuwkerk, Erik Stroes, Matthew Walters, Peter Higgins, Jesse Dawson, Paolo Gresele, Giuseppe Guglielmini, Rino Migliacci, Marat Ezhov, Maya Safarova, Tatyana Balakhonova, Eiichi Sato, Mayuko Amaha, Tsukasa Nakamura, Kostas Kapellas, Lisa M Jamieson, Michael Skilton, James A Blumenthal, Alan Hinderliter, Andrew Sherwood, Patrick J Smith, Michiel A Van Agtmael, Peter Reiss, Marit GA Van Vonderen, Stefan Kiechl, Gerhard Klingenschmid, Matthias Sitzer, Coen DA Stehouwer, Heiko Uthoff, Zhi-Yong Zou, Ana R Cunha, Mario F Neves, Miles D Witham, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Enrique Bernal, Kristian Wachtell, Sverre E Kjeldsen, Michael H Olsen, David Preiss, Naveed Sattar, Edith Beishuizen, Menno V Huisman, Mark A Espeland, Caroline Schmidt, Stefan Agewall, Ercan Ok, Gülay Aşçi, Eric De Groot, Muriel PC Grooteman, Peter J Blankestijn, Michiel L Bots, Michael J Sweeting, Simon G Thompson, Matthias W Lorenz, PROG-IMT and the Proof-ATHERO Study Groups
Publication date
2020/8/18
Journal
Circulation
Volume
142
Issue
7
Pages
621-642
Publisher
Lippincott Williams & Wilkins
Description
Background
To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk.
Methods
We systematically collated data from randomized, controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were used. The primary outcome was a combined CVD end point defined as myocardial infarction, stroke, revascularization procedures, or fatal CVD. We estimated intervention effects on cIMT progression and incident CVD for each trial, before relating the 2 using a Bayesian meta-regression approach.
Results
We analyzed data of 119 randomized, controlled trials involving 100 667 patients (mean age 62 years, 42% female). Over an average follow-up of 3.7 years, 12 038 patients developed the …
Scholar articles
P Willeit, L Tschiderer, E Allara, K Reuber, L Seekircher… - Circulation, 2020