Authors
James A Blumenthal, Andrew Sherwood, Michael A Babyak, Lana L Watkins, Patrick J Smith, Benson M Hoffman, C Virginia F O'Hayer, Stephanie Mabe, Julie Johnson, P Murali Doraiswamy, Wei Jiang, Douglas D Schocken, Alan L Hinderliter
Publication date
2012/9/18
Journal
Journal of the American College of Cardiology
Volume
60
Issue
12
Pages
1053-1063
Publisher
American College of Cardiology Foundation
Description
Objectives
The aim of this study was to assess the efficacy of exercise and antidepressant medication in reducing depressive symptoms and improving cardiovascular biomarkers in depressed patients with coronary heart disease.
Background
Although there is good evidence that clinical depression is associated with poor prognosis, optimal therapeutic strategies are currently not well defined.
Methods
One hundred one outpatients with coronary heart disease and elevated depressive symptoms underwent assessment of depression, including a psychiatric interview and the Hamilton Rating Scale for Depression. Participants were randomized to 4 months of aerobic exercise (3 times/week), sertraline (50–200 mg/day), or placebo. Additional assessments of cardiovascular biomarkers included measures of heart rate variability, endothelial function, baroreflex sensitivity, inflammation, and platelet function.
Results
After 16 …
Total citations
Scholar articles
JA Blumenthal, A Sherwood, MA Babyak, LL Watkins… - Journal of the American College of Cardiology, 2012