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Mixed model methodology was applied to estimate genetic trend of three rabbit strains (A, V and B) since there was no control line available. Strains A and V were selected on litter size at weaning by a selection index combining records on the doe, her mother, full sibs and half sibs. Strain B was selected on individual growth rate between 28 and 77 days. All strains were reared under the same conditions. Predictors of genetic values of litter size were obtained by using a repeatability model which included year-season of parity and reproductive state of the female (primiparous; lactating; non primiparous non lactating) as fixed effects. Variance components used to predict genetic value were estimated by using a large amount of data before selection. All relatives were considered when computing the relationship matrix. Genetic trend was estimated by regression of generation average of genetic predictors on …