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We study optimal interest-rate policy in a New Keynesian model in which the economy is at risk of experiencing a financial crisis and the probability of a crisis depends on credit conditions. The optimal adjustment to interest rates in response to credit conditions is (very) small when the model is calibrated to match an estimated historical relationship between credit conditions, output, inflation and the likelihood of financial crises. Given the imprecise estimates of a number of key parameters, we also study optimal policy taking parameter uncertainty into account. We find that both Bayesian and robust central banks will respond more aggressively to financial stability risks when the probability and severity of financial crises are uncertain.