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The electrocardiogram (ECG) signal can easily be affected by various types of noises while being recorded, which decreases the accuracy of subsequent diagnosis. Therefore, the efficient denoising of ECG signals has become an important research topic. In the paper, we proposed an efficient ECG denoising approach based on empirical mode decomposition (EMD), sample entropy, and improved threshold function. This method can better remove the noise of ECG signals and provide better diagnosis service for the computer‐based automatic medical system. The proposed work includes three stages of analysis: (1) EMD is used to decompose the signal into finite intrinsic mode functions (IMFs), and according to the sample entropy of each order of IMF following EMD, the order of IMFs denoised is determined; (2) the new threshold function is adopted to denoise these IMFs after the order of IMFs denoised is …