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The main purpose of this paper is to develop an efficient multi-stage methodology to predict carbon dioxide emissions based on two important variables including the energy consumption and economic growth using the clustering, prediction machine learning techniques, and dimensionality reduction. To do so, we use the self-organizing map clustering algorithm to cluster the data and the adaptive neuro-fuzzy inference system and artificial neural network to construct the prediction models in each cluster of the self-organizing map to predict carbon dioxide emissions considering a set of input parameters including economic growth and energy consumption in Group 20 nations. Furthermore, we use the singular value decomposition for dimensionality reduction and missing values’ prediction in the dataset. The results of the analysis of a real-world dataset found that the developed multi-stage approach was capable of …