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In this paper, a Bayesian wavelet-based denoising procedure for multicomponent images is proposed. A denoising procedure is constructed that 1) fully accounts for the multicomponent image covariances, 2) makes use of Gaussian scale mixtures as prior models that approximate the marginal distributions of the wavelet coefficients well, and 3) makes use of a noise-free image as extra prior information. It is shown that such prior information is available with specific multicomponent image data of, e.g., remote sensing and biomedical imaging. Experiments are conducted in these two domains, in both simulated and real noisy conditions.