Authors
Jie Jun Wong, Hongzhou Zhang, Fei Gao, Shuang Leng, Ru-San Tan, Xiaodan Zhao, Kieran Tan, Liang Zhong, Angela Su-Mei Koh
Publication date
2023/11/7
Journal
Circulation
Volume
148
Issue
Suppl_1
Pages
A12714-A12714
Publisher
Lippincott Williams & Wilkins
Description
Background: Traditional risk factors are less helpful in predicting cardiovascular (CV) risk in women (1, 2). We used a novel cardiac MRI (CMR) method to determine sex differences in aortic global longitudinal strain (AoGLS), pulse wave velocity (AAPWV), and ventriculoarterial coupling (VAC) and correlated to Framingham Risk Scores (FRS).
Methods: Community adults without CV disease underwent CMR. AoGLS was the maximal absolute Lagrangian strain tracking the phasic distance between brachiocephalic artery origin and aortic annulus. VAC was calculated as AAPWV divided by LVGLS. Sex-specific simplified FRS 10-year risk (TYR) and Heart/Vascular Age (HVA) were derived from pooled cohort equations (3).
Results: These n=202 subjects (46% female) were similar in age (69.7 vs. 70.7, p=0.433). Women had better AAPWV (8.4m/s vs. 9.1m/s, p=0.020), AoGLS (6.2% vs. 5.2%, p=0.030), LVGLS (-21.9 …
Scholar articles
JJ Wong, H Zhang, F Gao, S Leng, RS Tan, X Zhao… - Circulation, 2023