Authors
Jie Jun Wong, Louis LY Teo, Fei Gao, Liang Zhong, Weimin Huang, Nicholas Graves, Ru-San Tan, Terrance SJ Chua, Felix JY Keng, Angela S Koh
Publication date
2024/9/1
Journal
Health Policy and Technology
Volume
13
Issue
3
Pages
100881
Publisher
Elsevier
Description
Background
Recent advancements in quantifying myocardial blood flow (MBF) and coronary flow reserve using dynamic SPECT MPI have demonstrated comparable hemodynamic correlations with invasive angiography and PET. Implementation into routine practice, however, imposes attendant demands on resources. Diabetes mellitus is a rising pandemic associated with accelerated atherosclerosis, yet there is potential for under-detection of significant ischemia.
Objectives
We postulate that quantifying myocardial blood flow (MBF) by dynamic SPECT reduces post-test resource utilization and improve economic efficiency over conventional SPECT.
Methods
NUCLEuS is an ongoing prospective open-label randomized clinical trial that will enroll 300 diabetic patients without known coronary artery disease (CAD) referred clinically for SPECT MPI from March 2022 to March 2025. The aim is to determine the …
Scholar articles
JJ Wong, LLY Teo, F Gao, L Zhong, W Huang… - Health Policy and Technology, 2024