Authors
Zia Mehmood, Hosamadin Assadi, Rui Li, Bahman Kasmai, Gareth Matthews, Ciaran Grafton-Clarke, Aureo Sanz-Cepero, Xiaodan Zhao, Liang Zhong, Nay Aung, Kristian Skinner, Charaka Hadinnapola, Peter Swoboda, Andrew J Swift, Vassilios S Vassiliou, Christopher Miller, Rob J van der Geest, Stephen Peterson, Pankaj Garg
Publication date
2024/3/1
Source
Heart
Volume
110
Issue
Suppl 1
Pages
A25-A27
Publisher
BMJ Publishing Group Ltd and British Cardiovascular Society
Description
Introduction
There is growing interest in identifying cardiovascular magnetic resonance (CMR) signatures in ageing due to their relevance to cardiovascular health.1 It also remains uncertain whether patients with heart failure with preserved ejection fraction (HFpEF) have disruptions in their aortic flow. This study aimed to explore sophisticated indicators of aortic flow disturbances in ageing and in HFpEF.
Materials and Methods
This study used two-dimensional phase-contrast CMR data at an orthogonal plane just above the sino-tubular junction. We recruited 10 young healthy controls (HCs), 10 old HCs and 23 patients with HFpEF. We analysed average systolic aortic flow displacement (FDsavg), systolic flow reversal ratio (sFRR) and pulse wave velocity (PWV). In a sub-group analysis, we compared old HCs versus age-gender-matched HFpEF (N=10).
Results
Differences were significant in mean age (P<0.001 …
Scholar articles
Z Mehmood, H Assadi, R Li, B Kasmai, G Matthews… - 2024