Authors
Francisco M Marty, Luis Ostrosky-Zeichner, Oliver A Cornely, Kathleen M Mullane, John R Perfect, George R Thompson, George J Alangaden, Janice M Brown, David N Fredricks, Werner J Heinz, Raoul Herbrecht, Nikolai Klimko, Galina Klyasova, Johan A Maertens, Sameer R Melinkeri, Ilana Oren, Peter G Pappas, Zdeněk Ráčil, Galia Rahav, Rodrigo Santos, Stefan Schwartz, J Janne Vehreschild, Jo-Anne H Young, Ploenchan Chetchotisakd, Sutep Jaruratanasirikul, Souha S Kanj, Marc Engelhardt, Achim Kaufhold, Masanori Ito, Misun Lee, Carolyn Sasse, Rochelle M Maher, Bernhardt Zeiher, Maria JGT Vehreschild
Publication date
2016/7/1
Journal
The Lancet infectious diseases
Volume
16
Issue
7
Pages
828-837
Publisher
Elsevier
Description
Background
Mucormycosis is an uncommon invasive fungal disease with high mortality and few treatment options. Isavuconazole is a triazole active in vitro and in animal models against moulds of the order Mucorales. We assessed the efficacy and safety of isavuconazole for treatment of mucormycosis and compared its efficacy with amphotericin B in a matched case-control analysis.
Methods
In a single-arm open-label trial (VITAL study), adult patients (≥18 years) with invasive fungal disease caused by rare fungi, including mucormycosis, were recruited from 34 centres worldwide. Patients were given isavuconazole 200 mg (as its intravenous or oral water-soluble prodrug, isavuconazonium sulfate) three times daily for six doses, followed by 200 mg/day until invasive fungal disease resolution, failure, or for 180 days or more. The primary endpoint was independent data review committee-determined overall response …
Scholar articles
FM Marty, L Ostrosky-Zeichner, OA Cornely… - The Lancet infectious diseases, 2016