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Diabetes mellitus becomes a serious problem in most countries. A continuous plan and management for DM patients to control the blood glucose level and to monitor progress of DM’s complications becomes an important issue. We proposed an ontology-based development for clinical information system which enables health providers who are non-experts in Diabetes disease can suggest patients the essential activities for improving life quality and achieving goals of DM treatment. In this paper, we mainly focus on the ontology development process for Type II DM. There are three main steps, 1) domain and scope setting, 2) important terms acquisition, classes and class hierarchy conceptualization and 3) instances instantiation. We show an example of using reminding system which it developed based on our ontology.