Authors
Mikaela Smit, Kees Brinkman, Suzanne Geerlings, Colette Smit, Kalyani Thyagarajan, Ard van Sighem, Frank de Wolf, Timothy B Hallett
Publication date
2015/7/1
Journal
The Lancet infectious diseases
Volume
15
Issue
7
Pages
810-818
Publisher
Elsevier
Description
Background
The population infected with HIV is getting older and these people will increasingly develop age-related non-communicable diseases (NCDs). We aimed to quantify the scale of the change and the implications for HIV care in the Netherlands in the future.
Methods
We constructed an individual-based model of the ageing HIV-infected population, which followed patients on HIV treatment as they age, develop NCDs—including cardiovascular disease (hypertension, hypercholesterolaemia, myocardial infarctions, and strokes), diabetes, chronic kidney disease, osteoporosis, and non-AIDS malignancies—and start co-medication for these diseases. The model was parameterised by use of data for 10 278 patients from the national Dutch ATHENA cohort between 1996 and 2010. We made projections up to 2030.
Findings
Our model suggests that the median age of HIV-infected patients on combination …
Scholar articles
M Smit, K Brinkman, S Geerlings, C Smit… - The Lancet infectious diseases, 2015