Authors
Marc van der Valk, Peter H Bisschop, Johannes A Romijn, Mariette T Ackermans, Joep MA Lange, Erik Endert, Peter Reiss, Hans P Sauerwein
Publication date
2001/11/9
Journal
Aids
Volume
15
Issue
16
Pages
2093-2100
Publisher
LWW
Description
Background
Treatment for HIV-1 infection is complicated by fat redistribution (lipodystrophy). This is associated with insulin resistance concerning glucose uptake. Our aim was to characterize glucose metabolism more comprehensively in HIV-1-infected patients with lipodystrophy. We assessed glucose disposal and its pathways, glucose production, plasma free fatty acid (FFA) levels, and the degree to which these parameters could be suppressed by insulin.
Methods
Six HIV-1-infected men on protease inhibitor-based HAART with lipodystrophy (HIV+ LD) were studied. The results were compared with those in six matched healthy male volunteers. Insulin sensitivity was quantified by hyperinsulinemic euglycaemic clamp. Glucose production and uptake were assessed by tracer dilution employing 6, 6d 2-glucose.
Results
At post-absorptive insulin concentrations, glucose production was 47% higher in HIV+ LD than …
Total citations
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Scholar articles
M van der Valk, PH Bisschop, JA Romijn… - Aids, 2001