Authors
Siva Sankar Murthy Bandaru, Shatrughn Bhilare, Nicolas Chrysochos, Vijay Gayakhe, Ivan Trentin, Carola Schulzke, Anant R Kapdi
Publication date
2018/1/19
Journal
Organic letters
Volume
20
Issue
2
Pages
473-476
Publisher
American Chemical Society
Description
A mild and highly efficient catalytic amination procedure for chloroheteroarenes at ambient temperature using the Pd/PTABS catalytic system is reported. The protocol is selective for the amination of chloroheteroarenes using secondary amines such as piperidine, pyrrolidine, and several others. The exceptional mildness of the developed protocol is beneficial for the synthesis of a crucial Buparlisib intermediate as well as the formal synthesis of Alogliptin in competitive yields.
Scholar articles
SS Murthy Bandaru, S Bhilare, N Chrysochos… - Organic letters, 2018