Authors
Leo Gross, Fabian Mohn, Nikolaj Moll, Gerhard Meyer, Rainer Ebel, Wael M Abdel-Mageed, Marcel Jaspars
Publication date
2010/10
Journal
Nature chemistry
Volume
2
Issue
10
Pages
821-825
Publisher
Nature Publishing Group UK
Description
Nature offers a huge and only partially explored variety of small molecules with potential pharmaceutical applications. Commonly used characterization methods for natural products include spectroscopic techniques such as nuclear magnetic resonance spectroscopy and mass spectrometry. In some cases, however, these techniques do not succeed in the unambiguous determination of the chemical structure of unknown compounds. To validate the usefulness of scanning probe microscopy as an adjunct to the other tools available for organic structure analysis, we used the natural product cephalandole A, which had previously been misassigned, and later corrected. Our results, corroborated by density functional theory, demonstrate that direct imaging of an organic compound with atomic-resolution force microscopy facilitates the accurate determination of its chemical structure. We anticipate that our method may be …
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L Gross, F Mohn, N Moll, G Meyer, R Ebel… - Nature chemistry, 2010