Authors
Robert A Power, Katherine E Tansey, Henriette Nørmølle Buttenschøn, Sarah Cohen-Woods, Tim Bigdeli, Lynsey S Hall, Zoltán Kutalik, S Hong Lee, Stephan Ripke, Stacy Steinberg, Alexander Teumer, Alexander Viktorin, Naomi R Wray, Volker Arolt, Bernard T Baune, Dorret I Boomsma, Anders D Børglum, Enda M Byrne, Enrique Castelao, Nick Craddock, Ian W Craig, Udo Dannlowski, Ian J Deary, Franziska Degenhardt, Andreas J Forstner, Scott D Gordon, Hans J Grabe, Jakob Grove, Steven P Hamilton, Caroline Hayward, Andrew C Heath, Lynne J Hocking, Georg Homuth, Jouke J Hottenga, Stefan Kloiber, Jesper Krogh, Mikael Landén, Maren Lang, Douglas F Levinson, Paul Lichtenstein, Susanne Lucae, Donald J MacIntyre, Pamela Madden, Patrik KE Magnusson, Nicholas G Martin, Andrew M McIntosh, Christel M Middeldorp, Yuri Milaneschi, Grant W Montgomery, Ole Mors, Bertram Müller-Myhsok, Dale R Nyholt, Hogni Oskarsson, Michael J Owen, Sandosh Padmanabhan, Brenda WJH Penninx, Michele L Pergadia, David J Porteous, James B Potash, Martin Preisig, Margarita Rivera, Jianxin Shi, Stanley I Shyn, Engilbert Sigurdsson, Johannes H Smit, Blair H Smith, Hreinn Stefansson, Kari Stefansson, Jana Strohmaier, Patrick F Sullivan, Pippa Thomson, Thorgeir E Thorgeirsson, Sandra Van der Auwera, Myrna M Weissman, Gerome Breen, Cathryn M Lewis, CONVERGE Consortium, CARDIoGRAM Consortium, GERAD1 Consortium
Publication date
2017/2/15
Journal
Biological psychiatry
Volume
81
Issue
4
Pages
325-335
Publisher
Elsevier
Description
Background
Major depressive disorder (MDD) is a disabling mood disorder, and despite a known heritable component, a large meta-analysis of genome-wide association studies revealed no replicable genetic risk variants. Given prior evidence of heterogeneity by age at onset in MDD, we tested whether genome-wide significant risk variants for MDD could be identified in cases subdivided by age at onset.
Methods
Discovery case-control genome-wide association studies were performed where cases were stratified using increasing/decreasing age-at-onset cutoffs; significant single nucleotide polymorphisms were tested in nine independent replication samples, giving a total sample of 22,158 cases and 133,749 control subjects for subsetting. Polygenic score analysis was used to examine whether differences in shared genetic risk exists between earlier and adult-onset MDD with commonly comorbid disorders of …
Scholar articles
RA Power, KE Tansey, HN Buttenschøn… - Biological psychiatry, 2017