Authors
Patrick F Sullivan, Eco JC de Geus, Gonneke Willemsen, Michael R James, Jan H Smit, Tim Zandbelt, Volker Arolt, Bernhard T Baune, Douglas Blackwood, Sven Cichon, William L Coventry, Katharina Domschke, Anne Farmer, Maurizio Fava, Scott D Gordon, Qianchuan He, AC Heath, Peter Heutink, Florian Holsboer, Witte J Hoogendijk, Jouke Jan Hottenga, Yijuan Hu, Martin Kohli, Danyu Lin, Suzanne Lucae, Donald J MacIntyre, Wolfgang Maier, Kevin A McGhee, Peter McGuffin, GW Montgomery, Walter J Muir, WA Nolen, Markus M Nöthen, Roy H Perlis, Katrina Pirlo, Danielle Posthuma, Marcella Rietschel, Patizia Rizzu, Alexandra Schosser, August B Smit, Jordan W Smoller, Jung-Ying Tzeng, Richard van Dyck, Matthijs Verhage, Frans G Zitman, Nicholas G Martin, Naomi R Wray, Dorret I Boomsma, Brenda WJH Penninx
Publication date
2009/4
Journal
Molecular psychiatry
Volume
14
Issue
4
Pages
359-375
Publisher
Nature Publishing Group
Description
Major depressive disorder (MDD) is a common complex trait with enormous public health significance. As part of the Genetic Association Information Network initiative of the US Foundation for the National Institutes of Health, we conducted a genome-wide association study of 435 291 single nucleotide polymorphisms (SNPs) genotyped in 1738 MDD cases and 1802 controls selected to be at low liability for MDD. Of the top 200, 11 signals localized to a 167 kb region overlapping the gene piccolo (PCLO, whose protein product localizes to the cytomatrix of the presynaptic active zone and is important in monoaminergic neurotransmission in the brain) with P-values of 7.7× 10− 7 for rs2715148 and 1.2× 10− 6 for rs2522833. We undertook replication of SNPs in this region in five independent samples (6079 MDD independent cases and 5893 controls) but no SNP exceeded the replication significance threshold when …
Total citations
Scholar articles
PF Sullivan, EJC de Geus, G Willemsen, MR James… - Molecular psychiatry, 2009