Authors
M Futamura, J Yao, X Li, R Bergeron, J-L Tran, E Zycband, J Woods, Y Zhu, Q Shao, H Maruki-Uchida, H Goto-Shimazaki, RB Langdon, MD Erion, J Eiki, Y-P Zhou
Publication date
2012/4
Journal
Diabetologia
Volume
55
Pages
1071-1080
Publisher
Springer-Verlag
Description
Aims/hypothesis
Glucokinase activators (GKAs) are currently being developed as new therapies for type 2 diabetes and have been shown to enhance beta cell survival and proliferation in vitro. Here, we report the effects of chronic GKA treatment on the development of hyperglycaemia and beta cell loss in the male Zucker diabetic fatty (ZDF) rat, a model of type 2 diabetes with severe obesity.
Methods
Cell protection by GKA was studied in MIN6 and INS-1 cells exposed to hydrogen peroxide. Glucose homeostasis and beta cell mass were evaluated in ZDF rats dosed for 41 days with Cpd-C (a GKA) or glipizide (a sulfonylurea) as food admixtures at doses of approximately 3 and 10 mg kg−1 day−1.
Results
Incubation of MIN6 and INS-1 832/3 insulinoma cell cultures with GKA significantly reduced cell death and …
Scholar articles
M Futamura, J Yao, X Li, R Bergeron, JL Tran… - Diabetologia, 2012