Authors
Zhijian Lu, Joann Bohn, Raynald Bergeron, Qiaolin Deng, Kenneth P Ellsworth, Wayne M Geissler, Georgianna Harris, Peggy E McCann, Brian McKeever, Robert W Myers, Richard Saperstein, Christopher A Willoughby, Jun Yao, Kevin Chapman
Publication date
2003/11/17
Journal
Bioorganic & medicinal chemistry letters
Volume
13
Issue
22
Pages
4125-4128
Publisher
Pergamon
Description
A new class of diacid analogues that binds at the AMP site not only are very potent but have ∼10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed.
Total citations
Scholar articles
Z Lu, J Bohn, R Bergeron, Q Deng, KP Ellsworth… - Bioorganic & medicinal chemistry letters, 2003