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Psychopathy is a complex clinical condition conceptualized as a combination of personality features, including shallow affect and egocentricity, as well as behavioral features including impulsivity and poor behavioral controls. 1 It has been hypothesized that deficits in the fronto-temporal neural circuit, particularly the ventromedial prefrontal cortex, dorsolateral prefrontal cortex, medial temporal regions and cingulate cortex, may play crucial roles in the neurobiological bases of psychopathy. 2, 3 Prefrontal impairments, specifically, have been linked to poor decision making, whereas deficits in the temporal regions have been argued to contribute to the lack of emotion and social dysfunction in psychopathic individuals. We employed a cortical pattern-matching method, 4 to investigate localized differences in cortical gray matter thickness in psychopaths compared with that in non-psychopathic controls. We also …