Authors
Philippa J Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J Newhouse, Anna Dominiczak, Nilesh J Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C Shields, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, Shah Ebrahim, Michael G Marmot, George Davey Smith, Debbie A Lawlor, Patricia B Munroe, Ian N Day, Mika Kivimaki, John Whittaker, Steve E Humphries, Aroon D Hingorani
Publication date
2009/11/13
Journal
The American journal of human genetics
Volume
85
Issue
5
Pages
628-642
Publisher
Elsevier
Description
Blood lipids are important cardiovascular disease (CVD) risk factors with both genetic and environmental determinants. The Whitehall II study (n = 5592) was genotyped with the gene-centric HumanCVD BeadChip (Illumina). We identified 195 SNPs in 16 genes/regions associated with 3 major lipid fractions and 2 apolipoprotein components at p < 10−5, with the associations being broadly concordant with prior genome-wide analysis. SNPs associated with LDL cholesterol and apolipoprotein B were located in LDLR, PCSK9, APOB, CELSR2, HMGCR, CETP, the TOMM40-APOE-C1-C2-C4 cluster, and the APOA5-A4-C3-A1 cluster; SNPs associated with HDL cholesterol and apolipoprotein AI were in CETP, LPL, LIPC, APOA5-A4-C3-A1, and ABCA1; and SNPs associated with triglycerides in GCKR, BAZ1B, MLXIPL, LPL, and APOA5-A4-C3-A1. For 48 SNPs in previously unreported loci that were significant at p < 10 …
Total citations
Scholar articles
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
PJ Talmud, F Drenos, S Shah, T Shah, J Palmen… - The American journal of human genetics, 2009