Authors
Roy Lardenoije, Artemis Iatrou, Gunter Kenis, Konstantinos Kompotis, Harry WM Steinbusch, Diego Mastroeni, Paul Coleman, Cynthia A Lemere, Patrick R Hof, Daniel LA van den Hove, Bart PF Rutten
Publication date
2015/8/1
Source
Progress in neurobiology
Volume
131
Pages
21-64
Publisher
Pergamon
Description
Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as in more dynamic processes related to cognition. Epigenetic regulation covers multiple levels of gene expression; from direct modifications of the DNA and histone tails, regulating the level of transcription, to interactions with messenger RNAs, regulating the level of translation. Importantly, epigenetic dysregulation currently garners much attention as a pivotal player in aging and age-related neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may mediate interactions between genetic and environmental risk factors, or directly interact with disease-specific …
Total citations
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Scholar articles
R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in neurobiology, 2015