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As mindfulness research advances on a variety of fronts, it has become increasingly important to carefully define and measure the construct. In this commentary, we draw from our recent research experience on these topics in addressing four issues of primary concern to Bishop et al (see record 2004-15972-002): The nature of mindfulness, the role of acceptance in the phenomenon, the relation between mindfulness and meditation, and the measurement of mindfulness in meditative and other contexts.(PsycInfo Database Record (c) 2021 APA, all rights reserved)