Authors
Andrew S Levey, Juan P Bosch, Julia Breyer Lewis, Tom Greene, Nancy Rogers, David Roth, Modification of Diet in Renal Disease Study Group*
Publication date
1999/3/16
Journal
Annals of internal medicine
Volume
130
Issue
6
Pages
461-470
Publisher
American College of Physicians
Description
Background
Serum creatinine concentration is widely used as an index of renal function, but this concentration is affected by factors other than glomerular filtration rate (GFR).
Objective
To develop an equation to predict GFR from serum creatinine concentration and other factors.
Design
Cross-sectional study of GFR, creatinine clearance, serum creatinine concentration, and demographic and clinical characteristics in patients with chronic renal disease.
Patients
1628 patients enrolled in the baseline period of the Modification of Diet in Renal Disease (MDRD) Study, of whom 1070 were randomly selected as the training sample; the remaining 558 patients constituted the validation sample.
Methods
The prediction equation was developed by stepwise regression applied to the …
Total citations
Scholar articles
AS Levey, JP Bosch, JB Lewis, T Greene, N Rogers… - Annals of internal medicine, 1999
AS Levey, JP Bosch, JB Lewis, T Greene, N Rogers… - Ann Intern Med, 1999