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Two neutral complexes [ML] (where M = Pd (1a) and Pt (1b), L = bis(pyridine-2-carboxamide)benzene dianion) have been synthesized and characterized by physico-chemical and spectroscopic tools along with the detailed structural analysis by single crystal X-ray crystallography and theoretical (DFT) study. In solid state the compounds are isomorphous and isostructural showing the formation of [ML]₃·3H₂O trimeric species. Electrochemical study of 1a showed a quasi-reversible reductive response at E_1/2 = −1.148 V assignable to the Pd(II)/Pd(I) couple, while a metal centered irreversible oxidative peak centred at +0.977 V was observed in the voltammogram of 1b. The interaction of the complexes with CT-DNA has been investigated using spectroscopic tools and viscosity measurement. In each case the association constant (K_b) was deduced from the absorption spectral study and the number of binding sites (n …