Authors
Mohamed Farrag, Julie K Drobish, Henry L Puhl, Joyce S Kim, Paul B Herold, Marc P Kaufman, Victor Ruiz‐Velasco
Publication date
2017/12/1
Journal
The Journal of physiology
Volume
595
Issue
23
Pages
7167-7183
Description
Key points
- Chronic limb ischaemia, characterized by inflammatory mediator release and a low extracellular pH, leads to acid‐sensing ion channel (ASIC) activation and reflexively increases mean arterial pressure; endomorphin release is also increased under inflammatory conditions.
- We examined the modulation of ASIC currents by endomorphins in sensory neurons from rats with freely perfused and ligated femoral arteries: peripheral artery disease (PAD) model.
- Endomorphins potentiated sustained ASIC currents in both groups of dorsal root ganglion neurons, independent of mu opioid receptor stimulation or G protein activation.
- Intra‐arterial administration of lactic acid (to simulate exercising muscle and evoke a pressor reflex), endomorphin‐2 and naloxone resulted in a significantly greater pressor response than lactic acid alone, while administration of APETx2 inhibited endomorphin's enhancing effect in …
Scholar articles
M Farrag, JK Drobish, HL Puhl, JS Kim, PB Herold… - The Journal of physiology, 2017